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Importantly, the proteomic similarity of Day 30 iHLOs to PHHs, with a 33.46% expression difference from liver tissue, underscores their physiological relevance compared to traditional models like HepG2 cells, which exhibit a 54.36% protein difference from liver tissue, or HepaRG cells, with a 45.40% protein difference

The treatment options for opioid misuse include Medication-Assisted Treatment (MAT), Cognitive Behavioral Therapy (CBT), Residential or Inpatient Treatment, Outpatient Treatment, and Support Groups and Peer Support

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Thus, ischemic circulatory disorders in the brain lead to the development of hypoxic stress and the launch of adaptive mechanisms of endogenous neuroprotection

T-buooh induces ferroptosis in human and murine cell lines