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Terpinen-4-ol is considered to be the main active component but as a great article in Clinical Microbiology Reviews states " while some TTO components may be considered less active, none can be considered inactive " and most components contribute to TTO's strong antibacterial, antiviral and antifungal effects

For instance, there have been deaths associated with coffee enemas reported in the U.S.during the 80s

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10.1016/j.cell.2013.04.023 49 Czystowska-KuzmiczM.SosnowskaA.NowisD.RamjiK.SzajnikM.Chlebowska-TuzJ.et al

Functional imaging of focal brain activation in conscious rats: impact of [ 14 C]glucose metabolite spreading and release