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doi: 10.1016/j.ymgme.2018.11.001

Exp Cell Res (2019) 379(2):18290

March 19 Product: Takedas Iclusig Indication: Philadelphia chromosome-positive acute lymphoblastic leukemia Takeda scored a frontline approval for its kinase inhibitor Iclusig on Tuesday

3.1.1 Novel Levodopa Formulations and Delivery 3.1.1.1 Extended-Release Levodopa Efforts to increase levodopas half-life and thereby reduce motor fluctuations and prolong ON-time have started more than 5 decades ago with the introduction of sustained and controlled-release (CR) levodopa formulations [15,16,17], however the evidence base for the efficacy of the first-generation agents has remained slim [14]