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His work also has led to advances in the general understanding of how cells get rid of misfolded proteins that otherwise would accumulate and become toxic

[3] For example, the set of carboxylic acids that are best known as the intermediates in the citric acid cycle are present in all known organisms, being found in species as diverse as the unicellular bacterium Escherichia coli ( E

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Ox-LDL plays an important role in initiating and promoting the inflammatory response and leukocyte recruitment, which inhibits or damages the defense systems (e.g., antioxidant enzymes) of the cell, thereby decreasing its ability to scavenge oxygen free radicals and finally leading to vascular endothelial cell apoptosis (Yang et al., 2017)

This loss of Cx43 composed of functional gap junctions on the cell surface has deleterious effect on cellular homeostasis (Figure 7)