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However, many of these treatments are either ineffective or come with harmful side effects

In various diseases, multiple sites are modified simultaneously [123]

To compensate for such conditions, the retina upregulates signal molecules, namely VEGF, to stimulate neovascularization, or the formation of new blood vessels, in an attempt to continue nourishing the ischemic and hypoxic retinal cells [70]

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The carboxylate group of carnitine forms a salt bridge with the guanidinium group of R471 (TM11), as well as a hydrogen bonding interaction with the hydroxyl of Y447 (TM10), both residues from the C-terminal bundle