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However, when miR-190 was overexpressed, it led to a suppression of proinflammatory factors including iNOS, IL-6, TNF-, and TGF-1, while promoting the expression of anti-inflammatory factor IL-10

Experimentally, mice with conditional knockout of GPX4 in the cortex and hippocampus exhibit profound spatial memory deficits and hippocampal neurodegeneration (189)