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Reduced levels of SCFAs may lead to increased levels of BBB permeability, whilst TFAs have been found to increase phospholipid membrane rigidity, leading to altered neuronal signaling (24, 89)

Ofwats chief executive, David Black, said of the Thames business plan: Costs were poorly justified, service levels were unsatisfactory and so that makes our job more challenging. He said the response to Thames had been fair and that it was up to Thames to convince investors of its turnaround as it attempts to raise fresh funds