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As the available models do not accurately model the structure or filtration function of the glomerulus, their applications are limited

-Ketoglutarate is a TCA intermediate that results from the oxidative decarboxylation of isocitrate catalyzed by isocitrate dehydrogenase

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A single process underlying different hyperglycemia-induced pathogenic mechanisms: mitochondrial superoxide production Specific inhibitors of aldose-reductase activity, AGE formation, RAGE ligand binding, PKC activation and hexosamine pathway flux each ameliorate various diabetes-induced abnormalities in cell culture or animal models, but it has not been clear whether these processes are interconnected or might have a common cause [99,131134]

The analysis was also performed for Caucasian population alone which represented 67.2% of the study population