is glutathione fat soluble Metabolism - an overview Glutathione in Our Diet and

JAMA , 331(14), 12301231

Excretion Pathways Excretion mechanisms for both peptides remain incompletely characterized: Renal filtration likely represents primary elimination route for peptide fragments Hepatic metabolism may contribute to peptide degradation and clearance No evidence of significant biliary excretion in available studies Pharmacokinetic studies in renal or hepatic impairment models are absent from literature The rapid systemic clearance of both peptides contrasts with prolonged downstream effects on growth hormone and IGF-1, indicating that direct peptide presence is not required for sustained biological activity once pituitary signaling cascades are initiated

10.1002/ange.202008868 63 WangD.WuH.YangG.QianC.GuL.WangH.et al (2020)

Three hours after IL-22 stimulation, cells were harvested

First, they bypass the intestinal tract and second, they bypass the initial metabolism by your liver