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These receptors, in turn, influence EAAT2 expression, AQP4 polarization, and the astrocytic potential to produce cytokines

Importantly, drug-resistant tumor are more sensitive to lipid peroxidation, which undoubtedly makes, the combination of System X c /GSH/GPX4 axis-based ferroptosis inducers with chemotherapeutic agents may become a new strategy for the treatment of drug-resistant solid tumors (Viswanathan et al., 2017)

Because both alcohol and amitriptyline have sedating effects on the central nervous system, taking them together can amplify these effects

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Here is an example