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Not as an independent driver of weight loss the evidence for that is weak

Daratumumab triggers CD38 + multiple myeloma cells [via antibody-dependent cellular cytotoxicity (ADCC), complement dependent cytotoxicity (CDC), and tumor-associated macrophages (TAMs)] in sensitive and drug-resistant patients, regulates the enzyme activity of CD38, reduces the level of adenosine and reduces adenosine-induced immunosuppression

dosing of pyridoxine 180-600 mg daily (PO or IV)

Vegetarians and vegans are particularly at risk of this deficiency, as they do not consume animal-derived foods that are rich in Vitamin B12

Care has to be exercised particularly in lupus women during planning for pregnancy