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Another TKI, gefitinib (ZD1839, Iressa), which targets the epidermal growth factor receptor (EGFR), has been shown to restrict M.tb replication in both macrophages as well as in the lungs of M.tb -infected mice by promoting the host autophagy pathway through the inhibition of the p38 MAPK signaling pathway activated by EGFR [10]

P1 is under the regulation of Wnt signaling, therefore upregulation of Wnt leads to increased expression of LEF1

Now, this is correlation, not causation

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Age adjusted mortality rates (AAMRs) per 100,000 population were stratified by sex and race