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Epigenetic factors in late-onset alzheimers disease: MTHFR and CTH gene polymorphisms, metabolic transsulfuration and methylation pathways, and B vitamins

Digestion (2011) 84:1221

These agents can scavenge free radicals and prevent further damage (Jamshidi et al., 2018)

The activated AKT will further activate the downstream regulatory pathway (the downstream target is mTOR), and the conversion process can be reversed by PTEN (a negative regulatory factor of PI3K) through dephosphorylation of PIP3 (229)