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A notable feature of FMO3, the dominant liver form, is a polymorphism (a 551C-T mutation in exon 4) that changes a proline residue (153) to a leucine, resulting in an inactive enzyme

Natural foods typically dont cause neon yellow pee, but very high doses of certain nutrients, including beta-carotene in carrots or supplements, might shift the shade slightly

Nutrients, 14 (8), 1549

J Biol Chem 271(11):60006009

Impaired mitochondrial thiol redox homeostasis causes a similar phenomenon to TCA cycle inhibition, suggesting an important interaction between the TCA cycle, redox biology, and amino acid homeostasis (Ryan et al., 2021)