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Journal of Endocrinological Investigation, 45 (1), 111-119

Physiol., 280, H802-H811 34

Data collected from cerebrospinal fluid (CSF) biomarkers and positron emission tomography (PET) imaging from AD patients indicate that A is the first biomarker to accumulate, followed by the appearance of synaptic dysfunction and increased tau-protein concentrations 3

This was done using a CRISPR KO library composed of 655 druggable genes in 18 cell lines, ten of which were neuroblastoma lines, with the other eight being controls