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90,91 Additionally, the activity of epigenetics-modifying enzymes and their cofactors, such as TET and -ketoglutarate (-KG) from the tricarboxylic acid cycle (TCA), can be influenced by abnormal metabolite levels in patients with metabolic diseases, further disrupting epigenetic regulation and exacerbating disease progression

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Wang et al., A first-in-human, randomized, double-blind, single- and multiple-dose, phase I study of recombinant human thymosin 4 in healthy Chinese volunteers, J

This is divided into primary budd-chiari syndrome, caused by hepatic vein thrombosis and secondary budd-chiari syndrome, caused by venous obstruction by malignant tumours

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