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Adivitiya Kaushik MS, Chakraborty S, Veleri S, Kateriya S

Can too much vitamin C lead to kidney stones

The goal is to reduce pigment safely while lowering the risk of irritation or rebound darkening

43 , D364D368 (2015)

In a three-month study with 58 hypertensive patients, taking the anti-hypertensive drug nifedipine (a calcium channel blocker), the plasma levels of vasoconstrictor molecule endothelin-1 were significantly lowered by 9% after one month and by 16% after three months in the group taking 100 mg Pycnogenol compared to the placebo group (20)