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Accordingly, this review is presented with a particular emphasis on current thought with regard to the assessment of vitamin B-12 status and the diagnosis of deficiency, which have moved in recent years from sole measurement of serum total vitamin B-12 concentration to the measurement of multiple biomarkers of vitamin B-12 status, also known as multiple analyte testing. Current Status of Knowledge Basics of vitamin B-12 absorption and metabolism In-depth reviews of all facets of vitamin B-12 nutrition and metabolic functions are readily available (9, 10)

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