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Molecular Targets and Gene Therapy Targeting inflammation has emerged as a promising therapeutic approach in managing IRI, given the crucial role of the innate immune response in myocardial damage

It is characterized by microglial activation and enhanced release of inflammatory factors, such as tumor necrosis factor (TNF-), IL-2, IL-10, IL-4, IL-6, and interferon , which contribute to neuronal injury and death [30, 31]

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This imbalance leads to symptoms such as tachycardia, gastrointestinal dysregulation, dizziness, and orthostatic intolerance, worsening the clinical picture

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