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Numerous studies have documented a reduction in NAD + levels across various mouse tissues, including adipose (Yoshino et al., 2011), skeletal muscle (Frederick et al., 2015), liver (Trammell et al., 2016), and hypothalamus (Sasaki et al., 2014), concomitant with the development of obesity

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Pharmaceuticals 14(9):890 Meaney E et al (2012) Does metformin increase paraoxonase activity in patients with the metabolic syndrome