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Nevertheless, this enzyme clearly prefers the hypoxanthine-containing compounds over the adenine-containing ones

doi: 10.1126/science.1231143 299 HerrmannJEImuraTSongBQiJAoYNguyenTKet al

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The first step of the reaction mechanism involves formation of a spectroscopically distinct intermediate compound I (Figure 3(a)) which is a covalent oxyferryl species (Fe IV O) having a porphyrin -cation radical, through the reduction of one hydrogen peroxide molecule [11]