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Discussion The results of this study show that either the acute- or short-term administration of the peripheral DBH inhibitor, etamicastat, decreases blood pressure in both non-anesthetized and anesthetized mice with germ line deletion of Drd2 or renal-selective silencing of Drd2 (renal subcapsular infusion of Drd2 siRNA in D 2 +/+ mice) but not in wild-type littermates or D 2 +/+ mice that received renal subcapsular infusion of non-silencing siRNA