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The E-peptide identity problem A foundational uncertainty hangs over the entire MGF field: it is not established that the isolated E-domain peptide actually exists as an independent, cleaved product in living tissue

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The underlying mechanism of responsiveness generally entails structural destabilisation of the lipid bilayer upon exposure to a stimulus, which increases membrane permeability or causes vesicle disintegration, enabling the regulated and site-specific release of encapsulated substances

It was found that the ROS contents in serum after APP treatment did not increase as much as those in the APP-treated saline, while the NO content increased to about the same extent as those in APP-treated serum and saline