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10.1016/j.molcel.2018.06.002 Mol Cell

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Introduction The Developmental Origins of Health and Disease (DOHaD) hypothesis, first articulated by Barker and colleagues in the late 20th century, provides a conceptual framework for understanding how environmental exposures during critical periods of development shape long-term health trajectories [1,2]

Gluconeogenesis from glycerol but not from pyruvate is elevated in Insr P1195L/ + /HFD mice P1195L/ + Because severe insulin resistance in Insr P1195L/ +/HFD mice suggested unsuppressed gluconeogenesis in an otherwise insulin resistant liver, as is found in liver-specific Insr knockout (LIRKO) mice 7 , mRNA expressions of two key enzymes, phosphoenolpyruvate carboxykinase 1 ( Pck1 ) and glucose-6-phosphatase ( G6pc ), were examined (Fig