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Reactivation of dihydroorotate dehydrogenase-driven pyrimidine biosynthesis restores tumor growth of respiration-deficient cancer cells

This structure of the IGF1RIGF complex likely represents an intermedia state during IGF1R activation, however, as the two FnIII-3 domains (and presumably the kinase domains connected to them) remain separated by a long distance

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doi: 10.3389/fphar.2022.998179 Received 19 July 2022 Accepted 17 August 2022 Published 06 October 2022 Volume 13 - 2022 Edited by Tariq Ismail, Comsats University Islamabad, Pakistan Reviewed by Marcelino Maneiro, University of Santiago de Compostela, Spain Aisha Ayaz, Combined Military Hospital, Pakistan Updates Copyright 2022 Bulama, Nasiru, Bello, Abbas, Nasiru, Saidu, Chiroma, Mohd Moklas, Mat Taib, Waziri and Suleman