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Figure 4 shows the significant coefficient of the socially lagged variable and provides statistical evidence for the effect of social networks on the spatial spread of OOD rates

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[5] Systemically elevated estradiol exerts negative feedback on the hypothalamic-pituitary-gonadal axis, reducing secretion of luteinizing hormone and follicle-stimulating hormone, a property leveraged therapeutically in certain hypoestrogenic states to stabilize hormonal milieu and mitigate vasomotor volatility

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