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At physiologic pH (such as in serum and joint tissues), uric acid (which is a weak acid) exists as the anion urate, and plasma protein binding is quite low for urate

Elevated levels of CHAC1, often induced by ER stress, lead to reduced GSH levels, increased oxidative stress, and greater vulnerability to cell death processes like ferroptosis

Mitochondrial damage in Alzheimers disease varies with apolipoprotein E genotype

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Esterified AA is hydrolysed by phospholipase A 2 into a free form that is further metabolized by COX, LOX and CYP450 to a wide range of bioactive mediators, including prostaglandins, lipoxins, thromboxanes, leukotrienes, hydroxyeicosatetraenoic acids and epoxyeicosatrienoic acids