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Gln metabolism directly or indirectly influences epigenetic processes, such as DNA methylation and histone modification, through mechanisms of substrate supply and cofactor regulation

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Thus, the PPPgenerated NADPH rescues xCT-overexpressing cancer cells (xCT high cancer cells) from ferroptosis, demonstrating that xCT high cancer cells become highly dependent on the glucose-PPP pathway (i.e., NADPH addiction) to inhibit ferroptosis [Figure 1A]

Detoxification, methylation and anti-oxidants continue to play an important role in the biomedical treatment of autism and other chronic medical conditions

The first class comprises all antioxidants that cells can synthesize from smaller building blocks