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Hydroperoxides can then be reduced to form hydroxyl intermediates (HETE and hydroxy-octadecadienoic acid (HODE)) and further dehydrogenated to form ketone intermediates (oxo-eicosatetraenoic acid (oxoETE) and oxo-octadecadienoic acid (oxoODE)) ( Reference Yuan, Rapoport and Soldin 62 )

9 Toxicology and side effects Current evidence reveals an intrinsic paradox between therapeutic efficacy and safety profiles of bioactive compounds - no identified pharmacologically active agent completely avoids non-specific off-target effects on healthy tissues ( in vitro study demonstrated that shikonin has potent cytotoxicity against 15 types of cancer cells through mitochondrial dysfunction and can induce apoptosis

E., Deelchand, D., Henry, P

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Speliotes 4 , (1)University of Michigan School of Medicine, (2)University of Michigan, (3)University of Michigan, Ann Arbor, MI, (4)University of Michigan Medical School Background: Primary hepatocytes are difficult to obtain and dedifferentiate quickly in cell culture making them challenging to use to model chronic liver disease