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Reversible and irreversible CAR off-switches and CAR engineering, such as GM-CSF knockdown, are being investigated to reduce toxicities while maintaining therapeutic advantages [349]

This could signal pancreatitis, which requires urgent medical attention

Obvious limitations in obtaining sufficient liver tissue for molecular studies, as well as ethical challenges for performing paired liver biopsies before and after a given intervention, have greatly hampered our ability to make significant progress in understanding the pathogenesis of NASH in humans