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Upon reaching a tumor volume of ~500 mm 3 , the 4T1 tumor-bearing mice were randomly divided into two groups (12 mice per group) and intravenously administered either DOXHCl (2 mg/kg) or a combination of 6a (17 mg/kg) and 5c (2.4 mg/kg)

More robust red fluorescent signal was observed for primary cardiomyocytes in the control and PQQ treatment groups, whereas PE treatment was associated with increased green signal that was reduced when cells were treated with both PE and PQQ

Ethics declarations Ethics approval and consent to participate This study was performed with the approval of the Ethics Committee of Harbin Institute of Technology University and carried out in compliance with the Declaration of Helsinki of the World Medical Association

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As the livers primary tool for detoxification and its main shield against oxidative stress, glutathione is non-negotiable for long-term health