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The role of fluorine substitution in biphenyl methylene imidazole type CYP17 inhibitors for the treatment of prostate carcinoma

A physiological role for the transferase reaction has not been demonstrated

Remarkably, 2 weeks after the initial treatment, a strong inhibition on tumor growth progression was observed in the animal groups inoculated with BSO in combination with either cisplatin or with TMZ (Figure 6b)