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A program without a target cannot be optimized through medicinal chemistry, cannot generate target-engagement biomarkers and cannot be de-risked for off-target liabilities

These studies, although limited, indicate that DHEA and DHEA-S may represent a viable strategy to treat elderly estrogen-deprived skin wounds

In addition, NO levels in seminal plasma were shown to be elevated in individuals who scored higher on the State Anxiety Index questionnaire (168)

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