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More information on this work Shen, L

Li Y, Zhang C, Cheng H et al (2024) FOXO4-DRI improves spermatogenesis in aged mice through reducing senescence-associated secretory phenotype secretion from Leydig cells

The more direct evidence is mainly from the following reports

Common Side Effects: Gastrointestinal issues: Nausea Vomiting Diarrhea Abdominal pain Constipation General Discomfort: Fatigue Dizziness Headache Injection Site Reactions: Pain Redness Swelling Hypoglycemia low blood-glucose levels (especially if taken with other diabetes medications): Shaking Sweating Fast heartbeat Blurred vision Dizziness Tingling hands/feet Serious Side Effects (Less Common): If you experience any of the following, seek medical attention immediately: Pancreatitis: Severe abdominal pain, nausea, and vomiting

Biochemical and Serologic Abnormalities Biochemical cholestasis of at least 6 months duration gives reason to suspect PSC