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L-Glutathione

372 Although 17-AAG has demonstrated safety in oncology, its limited bloodbrain barrier permeability constrains its utility in NDDs, while 17-DMAG exhibits improved solubility but unacceptable toxicity

For instance, in a cohort of 139 individuals, 82.8% of those with ABCG1 promoter hypermethylation were found to have CHD, whereas only 17.4% of individuals without hypermethylation exhibited the condition