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Decreased abundance of Bacteroides in PSO patients indicating that decreased abundance of beneficial microorganisms may disturb skin homeostasis by altering the balance of the immune system ( Current immunologic studies have revealed the important role of immune pathways involving interleukin (IL)-17 in PSO ( Bacillus hominis (Bu) has been found to attenuate colitis by modulating host Bile Acids (BAs) metabolism, impacting the IL-17 signaling pathway, and inhibiting Th17 cell differentiation ( Lactobacillus pentosus decrease the suppression of pro-inflammatory cytokines, such as TNF-, IL-17A, and IL-23 ( In this study, we examined and observed the alterations in gut microbiomes in 14 PSO patients compared to 10 healthy subjects using 16S rRNA sequencing

doi: 10.1146/annurev-ento-120220-112317 48 KolliopoulouAVan NieuwerburghFStravopodisDJDeforceDSweversLSmaggheG