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Despite the remarkable advances in these fields, the structure-activity relationship is still complicated and remains to be further explored for the improved efficiency

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Recently, HDAC inhibition by butyrate was shown to affect the expression of P-glycoprotein, an ATP-binding cassette (ABC) protein known as a multi-drug resistance transporter that protects cells via efflux of toxins and xenobiotics (106)

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But critically, it does so in a regulated wayit doesnt stimulate abnormal or excessive cell growth the way cancerous processes do