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Since the discovery of the genetic etiology of AS, extensive efforts have been devoted to the understanding of the underlying mechanisms of AS pathophysiology, mainly by utilizing the AS mouse model, which was shown to replicate multiple phenotypes of the human disorder [5, 6]

As mentioned above, the first is stimulation of the AT1 receptor by angiotensin II which further activates phospholipase C and its activation leads to an increase in cytosolic Ca 2+ concentration

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According to the United Nations Children's Fund (UNICEF), lack of correct nutrition when pregnant accounts for 50% of maternal fatalities annually, and it is the main factor causing unfavourable pregnancy outcomes, being among the world's most pressing reproductive health issues

In addition, tamibarotene (a synthetic retinoid) is from the same family as ATRA, but is more potent and chemically stable than ATRA