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Second, GLP-1 secretion by engineered bacteria does not recapitulate the physiologically pulsatile release pattern of native L-cells, which depends on nutrient-derived stimuli, Ca 2+ signaling, and coordinated enteroendocrine regulation (Galsgaard et al., 2025)

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We speculate that GSH is converted to cystine extracellularly, as is the case with cysteine, or that GSH can be directly imported into the cells through mechanisms independent of Xc-