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Studying the anti-tyrosinase effect of Arbutus andrachne L

Arg1, arginase 1

Gpx4 is a crucial intracellular lipid peroxidation-detoxifying enzyme (Yant et al., 2003), and its inactivation not only participates in ferroptosis but also remains the main mechanism supporting this process (Krantz et al., 2005

About 50% of patients with melanoma have BRAF mutations and 1520% of NRAS mutations leading to the constitutive activation of the MAPK signaling pathway [2] and Chattopadhyay et al

Meanwhile, the NBDD delivery system also possesses limitations, for example, drug degradation, mucociliary clearance, and less residence time in the nasal cavity