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Common Scenarios : Frequently used in routine B12 injections for maintenance therapy or for initial loading doses in patients with B12 deficiency

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Another set of B12 deficiency symptoms are neurological, such as irritability, memory problems, depression, visual disturbances, tingling or numbness of hands and feet, pins and needles and eventually, in severe cases, a dementia-like illness, psychosis with hallucinations and paranoia (EFSA, 2015

However: direct clinical evidence remains limited

Teubner BJ, Garretson JT, Hwang Y, Cole PA, Bartness TJ