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erinaceus (polysaccharide, ethanol extracts, and cumulative fractions) for 14 days led to a significant clinical and histological improvement with a reduced neutrophil infiltration and a recovery of the pro-inflammatory/anti-inflammatory cytokine balance

In fact, glioma patients responded well to TMZ and, when administered in combination with radiotherapy, a significant improvement in the 2-year survival rate was observed (27% versus 10%)

257,259 Moreover, JAK3 mutations have been shown to lead to severe immunodeficiencies, whereas STAT3 mutations impair IL-17 production, which increases susceptibility to bacterial and fungal infections

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Tests of normality were employed to inform downstream parametric or non-parametric analyses