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In a rat ischaemic wound model, topical treatment with glutathione decreased oxidative stress leading to re-establishment of the MMP-1/TIMP-1 ratio which resulted in regular extracellular matrix production and re-epithelization 36

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When performed by certified healthcare professionals, IV therapy is widely regarded as safe

In general, studies included a low to moderate number of participants, but were either not controlled for confounding or were controlled only for age, rarely for other important variables