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18,19 Although heavy metal toxicities due to lead, mercury, and cadmium are generally considered rare in mainstream medicine, less well-recognized is that chronic accumulation that may not achieve classical acute toxicity thresholds may nevertheless contribute to adverse health effects

We also recently reported that supplying water with caffeine, which may offer potential benefits in reducing ROS in the brain, can enhance the preservation of the BBB in an animal model of AD, resulting in neuroprotective effects through anti-inflammatory responses in the CNS [53,54,60,63,64]