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References: Specific Cardiac Diseases Circulatory System Veterinary Manual

Glycosaminoglycans and WNTs: just a spoonful of sugar helps the signal go down

A recent study showed that the accumulation of UA in DNA-damaged tumors activates TAK1 and its downstream kinases, JNK, and AMPK, to phosphorylate ULK1 S555 and initiate autophagy [215](Fig

222 Currently, researchers have indicated that the aging process is accompanied by changes in mitochondria, including the increase of mtDNA mutations, changes in mitochondrial metabolism and mitophagy, the breakdown of mitochondrial dynamic balance, etc