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These observations imply that the nanoparticles can readily achieve a uniformly dispersed state in both weakly acidic and weakly alkaline conditions, rendering them suitable for physiological environments (Figure S1A-D)

Cell Metabolism 28(3):516-524. [doi.org]

To gain a deeper understanding of the clinical application of oHSVs, we conducted a review of 34 published oHSV clinical trials spanning the past two decades ( Table 2 )

Whilst one meta-analysis of 24 RCTs found a decrease in the pro-inflammatory markers C-reactive protein (CRP) and interleukin-6 (IL-6), 15 the other (based on 28 studies) found a decrease in interleukin-8 (IL-8) when pooling all data and a decrease in IL-6 in a subset of studies using a dose of 1200 mg NAC per day or less, but no difference in CRP

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