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Clinical trials had shown significant improvements in insulin sensitivity and HbA1c when patients were given vitamin D 3 [171, 172]

2.14 Animal model and experimental protocol 2.14.1 Establishment of ischemia-reperfusion mouse model and drug administration protocol Mice (C57BL/6 strain) were housed under controlled environmental conditions with a 12-hour light/dark cycle and ad libitum access to standard rodent chow and water