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The cannabinoid-mediated reduction in neurotransmitter release is achieved by the reduced influx of presynaptic Ca 2+ due to the inhibition of voltage gated Ca 2+ channels and of adenylyl cyclase, which downregulates cyclic adenosine monophosphate and protein kinase A, two cellular constituents involved in increasing the influx of Ca 2+ (Castillo et al., 2012)

Chronic increases in ROS, pro-inflammatory cytokines and other damaging compounds released from immune cells and astrocytes have the ability to damage mature oligodendrocytes and OPCs, resulting in myelination impairments (Pang et al., 2003

Polymorphisms in genes encoding drug-metabolizing enzymes, such as CYP450, can alter the way drugs are processed in the liver, making genetic screening a potential tool for identifying individuals at higher risk for DILI [92]

Amino Acids 30 , 495498 (2006)

Supporting Detoxification and Immunity GSH aids detoxification by binding to toxins in the liver for elimination and supports immunity by promoting healthy immune cell function