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Mirvetuximab soravtansine is an example of an ADC where the antibody mirvetuximab (anti-folate receptor , or anti-FR) is linked to a cytotoxic drug called DM4 (a maytansinoid)

Moreover, disease-induced alterations in Mn transporters and metabolism, and how these changes, in turn, exacerbate disease progression, remain largely unexplored

These methods include altering the molecular structure of peptides, using brain-targeting techniques, or conjugating peptides with carriers to enhance their permeability across the BBB

These highly reactive carbon-centered radicals then swiftly engage with oxygen, producing PUFA peroxyradicals (PUFA-OO), and culminating in the generation of PUFA hydroperoxides (PUFA-OOH) [47]

The Euclidean distance between the Scc2 hook and Scc4 is compatible with the distance between their respective interaction sites on Sth1, the ATPase module and its Sth1 N-terminal extension, respectively