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Vitamin A is essential for the developing CNS where it affects neurogenesis and neuronal patterning, but keeps playing an important role in the adult brain by regulating neuroplasticity in cerebral structures [100]

Consequently, any skin irritation with basement membrane disruption can deteriorate melasma condition and also induce persistence or recurrence type of the disease (Kwon et al., 2016)

These clinical trials, although very important to determine the effectiveness of the strain and the potential harmful effects, are particularly expensive, time-consuming and difficult to implement (8)

Thromb Res (2022) 213 Suppl 1:S3535S41

Pol J Environ Stud 30(4):30333042